Neonatal sepsis Secondary to Listeria Monocytogenes, Case report
DOI:
https://doi.org/10.61708/1xjefr72Keywords:
newborn, neonatal sepsis, Monocytogenes ListeriaAbstract
Listeriosis is a low-incidence infectious disease with an insidious clinical course in the general population. However, maternal–fetal transmission can lead to severe complications in newborns, including sepsis, meningitis, endocarditis, and central nervous system infections. Early diagnosis, based on the correlation between clinical and laboratory findings, together with the prompt initiation of appropriate antibiotic therapy, is crucial to improve prognosis and reduce neonatal mortality.
We report the case of a full-term neonate, delivered by repeat cesarean section with meconium-stained amniotic fluid. The patient presented with early signs of sepsis, prompting infectious workup that revealed positive blood cultures for Listeria monocytogenes. The diagnosis of neonatal sepsis with central nervous system involvement was established, and intravenous antibiotic therapy was initiated. After completing the therapeutic regimen, the patient demonstrated a favorable clinical course without significant complications. Our objective is to highlight the importance of early diagnosis and timely treatment in neonatal listeriosis, as it should be considered among the differential diagnoses of early- onset sepsis, in order to prevent severe complications and achieve a favorable clinical outcome.
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Wu F, Nizar S, Zhang L, Wang F, Lin X, Zhou X. Clinical features and antibiotic treatment of early-onset neonatal listeriosis. J Int Med Res [Internet]. agosto de 2022 [citado el 10 de noviembre de 2025];50(8):03000605221117207. Disponible en: https://journals.sagepub.com/doi/10.1177/03000605221117207 https://doi.org/10.1177/03000605221117207 DOI: https://doi.org/10.1177/03000605221117207
Jeffs E, Williman J, Brunton C, Gullam J, Walls T. The epidemiology of listeriosis in pregnant women and children in New Zealand from 1997 to 2016: an observational study. BMC Public Health. el 28 de enero de 2020;20(1):116. https://doi.org/10.1186/s12889-020-8221-z DOI: https://doi.org/10.1186/s12889-020-8221-z
Charlier C, Kermorvant-Duchemin E, Perrodeau E, Moura A, Maury MM, Bracq-Dieye H, et al. Neonatal Listeriosis Presentation and Outcome: A Prospective Study of 189 Cases. Clinical Infectious Diseases [Internet]. el 7 de enero de 2022 [citado el 10 de noviembre de 2025];74(1):8-16. Disponible en: https://academic.oup.com/cid/article/74/1/8/6238637 https://doi.org/10.1093/cid/ciab337 DOI: https://doi.org/10.1093/cid/ciab337
Zhan Y, Xu T, Liu H, Wang X, Yu H. Perinatal Infection with Listeria monocytogenes: A 10-Year Hospital-Based Study in Western China. J Inflamm Res. 2023;16:1243-54. https://doi.org/10.2147/JIR.S401171 DOI: https://doi.org/10.2147/JIR.S401171
Santos RP, Tristram D. A Practical Guide to the Diagnosis, Treatment, and Prevention of Neonatal Infections. Pediatric Clinics of North America [Internet]. el 1 de abril de 2015 [citado el 10 de noviembre de 2025];62(2):491-508. Disponible en: https://www.sciencedirect.com/science/article/pii/S0031395514002557 https://doi.org/10.1016/j.pcl.2014.11.010
Xu W, Peng MJ, Lu LS, Guo ZJ, Li AM, Li J, et al. Clinical Characteristics and Fatality Risk Factors for Patients with Listeria monocytogenes Infection: A 12-Year Hospital-Based Study in Xi'an, China. Infect Dis Ther [Internet]. junio de 2024 [citado el 10 de noviembre de 2025];13(6):1359-78. Disponible en: https://pmc.ncbi.nlm.nih.gov/articles/PMC11128421/ https://doi.org/10.1007/s40121-024-00986-3 DOI: https://doi.org/10.1007/s40121-024-00986-3
Zhang S, Li J, Wan L, Yu J, Chen S, Jin Z. Clinical Features and Antibiotic Treatment of Neonatal Listeriosis: A Hospital- Based Study. Infect Drug Resist. 2023;16:6647-59. https://doi.org/10.2147/IDR.S431402 DOI: https://doi.org/10.2147/IDR.S431402
Sola A, Mir R, Lemus L, Fariña D, Ortiz J, Golombek S, et al. Suspected Neonatal Sepsis: Tenth Clinical Consensus of the Ibero-American Society of Neonatology (SIBEN). Neoreviews. agosto de 2020;21(8):e505-34. https://doi.org/10.1542/neo.21-8-e505 DOI: https://doi.org/10.1542/neo.21-8-e505
Santos RP, Tristram D. A practical guide to the diagnosis, treatment, and prevention of neonatal infections. Pediatria Clin North Am. abril de 2015;62(2):491-508. https://doi.org/10.1016/j.pcl.2014.11.010 DOI: https://doi.org/10.1016/j.pcl.2014.11.010
Vergnano S, Godbole G, Simbo A, Smith-Palmer A, Cormican M, Anthony M, et al. Listeria infection in young infants: results from a national surveillance study in the UK and Ireland. Arch Dis Child. diciembre de 2021;106(12):1207-10. https://doi.org/10.1136/archdischild-2021-321602 DOI: https://doi.org/10.1136/archdischild-2021-321602
Bongiovanni M, Cavallo C, Barda B, Strulak L, Bernasconi E, Cardia A. Clinical Findings of Listeria monocytogenes Infections with a Special Focus on Bone Localizations. Microrganismos. el 16 de enero de 2024;12(1):178. https://doi.org/10.3390/microorganisms12010178 DOI: https://doi.org/10.3390/microorganisms12010178
Charlier C, Barrault Z, Rousseau J, Kermorvant-Duchemin E, Meyzer C, Semeraro M, et al. Long-term neurological and neurodevelopmental outcome of neonatal listeriosis in France: a prospective, matched, observational cohort study. The Lancet Child & Adolescent Health [Internet]. el 1 de diciembre de 2023 [citado el 10 de noviembre de 2025];7(12):875-85. Disponible en: https://www.sciencedirect.com/science/article/pii/S2352464223001955 https://doi.org/10.1016/S2352-4642(23)00195-5 DOI: https://doi.org/10.1016/S2352-4642(23)00195-5
Zou M, Yang J, Wiechers C, Huehn J. Acute neonatal Listeria monocytogenes infection causes long-term, organ-specific changes in immune cell subset composition. Eur J Microbiol Immunol (Bp). el 19 de junio de 2020;10(2):98-106. https://doi.org/10.1556/1886.2020.00007 DOI: https://doi.org/10.1556/1886.2020.00007
Arumugam SK, Govindharaj K, Subramaniam A, Rangasamy R. Neonatal Listeria innocua sepsis. Int J Contemp Pediatr [Internet]. el 27 de abril de 2021 [citado el 10 de noviembre de 2025];8(5):938. Disponible en: https://www.ijpediatrics.com/index.php/ijcp/article/view/4127 https://doi.org/10.18203/2349-3291.ijcp20211691 DOI: https://doi.org/10.18203/2349-3291.ijcp20211691
Álvarez Calatayud G, Manrique Martínez I, Gómez Campderá JA. Guía de tratamiento de las enfermedades infecciosas en urgencias pediátricas. Madrid: Drug Farma; 2002.
Neonatal infection: antibiotics for prevention and treatment [Internet]. London: National Institute for Health and Care Excellence (NICE); 2024 [citado el 10 de noviembre de 2025]. (National Institute for Health and Care Excellence: Guidelines). Disponible en: http://www.ncbi.nlm.nih.gov/books/NBK571222/
Kraus V, Čižmárová B, Birková A. Listeria in Pregnancy- The Forgotten Culprit. Microorganisms [Internet]. el 21 de octubre de 2024 [citado el 10 de noviembre de 2025];12(10):2102. Disponible en: https://www.mdpi.com/2076-2607/12/10/2102 https://doi.org/10.3390/microorganisms12102102 DOI: https://doi.org/10.3390/microorganisms12102102
Kleinman K, Mc Daniel L, Molloy M. The Harriet Lane Handbook [Internet]. Edición 22. España: Elsevier; 2023 [citado el 22 de noviembre de 2025]. 641-652 p. Disponible en: https://shop.elsevier.com/books/the-harriet-lane-handbook/anderson/978-0-323-87698-8
Reguera RM. Interpretación del líquido cefalorraquídeo. Anales de Pediatria Continua [Internet]. el 1 de enero de 2014 [citado el 9 de noviembre de 2025];12(1):30-3. Disponible en: http://www.elsevier.es/es-revista-anales-pediatria-continuada-51-articulo-interpretacion-del-liquido-cefalorraquideo-S1696281814701647 https://doi.org/10.1016/S1696-2818(14)70164-7 DOI: https://doi.org/10.1016/S1696-2818(14)70164-7
Fernandez B, López J, Coto G, Ramos A, Fernadez A. Sepsis del Recien nacido. Protocolos Diagnóstico AEP: Neonatología [Internet]. 2008;1(1):190-5. Disponible en: https://www.aeped.es/sites/default/files/documentos/21_0.pdf
Troncoso A L, Menéndez G P, Hernández Ch M. Convulsiones neonatales: diagnóstico y manejo. Revista chilena de pediatría [Internet]. mayo de 2001 [citado el 10 de noviembre de 2025];72(3):190-8. Disponible en: http://www.scielo.cl/scielo.php?script=sci_abstract&pid=S0370-41062001000300002&lng=es&nrm=iso&tlng=es https://doi.org/10.4067/S0370-41062001000300002 DOI: https://doi.org/10.4067/S0370-41062001000300002
Velaphi S, Mokhachane M, Mphahlele R, Beckh-Arnold E. Effect of prophylactic phenobarbital on seizures, encephalopathy and mortality in neonates with perinatal asphyxia. South African Journal of Child Health [Internet]. enero de 2013 [citado el 10 de noviembre de 2025];7(1):17-21. Disponible en: http://www.scielo.org.za/scielo.php?script=sci_abstract&pid=S1999-76712013000100005&lng=en&nrm=iso&tlng=en https://doi.org/10.7196/sajch.494 DOI: https://doi.org/10.7196/sajch.494
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