IgA vasculitis with gastrointestinal involvement in a young adult patient: Case report
DOI:
https://doi.org/10.61708/8xcrw874Keywords:
vasculitis, IgA vasculitis, Henoch-Schönlein purpura, clinical diagnosisAbstract
Immunoglobulin A vasculitis (IgAV) is caused by systemic hypersensitivity due to the deposition of immune complexes in small blood vessels, including the renal glomeruli and mesangium. It is predominant in children, although a small percentage may occur in adults, with an annual incidence of 0.1 to 1.8 per 100,000 people. This clinical case is described in a young adult patient who presented for consultation with odynophagia, unquantified fever, and generalized arthralgia, accompanied by abdominal pain. He subsequently developed hematemesis, and no kidney damage was evident during the initial evaluation. To detail an atypical clinical presentation and its implications during the diagnostic approach.
Downloads
References
Jennette JC, Falk RJ, Bacon PA, Basu N, Cid MC, Ferrario F, et al. 2012 revised International Chapel Hill Consensus Conference Nomenclature of Vasculitides. Arthritis Rheum. 2013;65(1):1-11. https://doi.org/10.1002/art.37715 DOI: https://doi.org/10.1002/art.37715
Maritati F, Canzian A, Fenaroli P, Vaglio A. Adult-onset IgA vasculitis (Henoch-Schönlein): Update on therapy. Presse Médicale. 2020;49(3):104035. https://doi.org/10.1016/j.lpm.2020.104035 DOI: https://doi.org/10.1016/j.lpm.2020.104035
Yaseen K, Herlitz LC, Villa-Forte A. IgA Vasculitis in Adults: a Rare yet Challenging Disease. Curr Rheumatol Rep. 2021;23(7):50. https://doi.org/10.1007/s11926-021-01013-x DOI: https://doi.org/10.1007/s11926-021-01013-x
Tadokoro T, Abe T, Nakano T, Kimura Y, Higaki K, Hayashidani S, et al. IgA vasculitis. QJM Mon J Assoc Physicians. 2023;116(7):538-9. https://doi.org/10.1093/qjmed/hcad038 DOI: https://doi.org/10.1093/qjmed/hcad038
Lai L, Liu S, Azrad M, Hall S, Hao C, Novak J, et al. IgA Vasculitis with Nephritis in Adults: Histological and Clinical Assessment. J Clin Med. 2021;10(21):4851. https://doi.org/10.3390/jcm10214851 DOI: https://doi.org/10.3390/jcm10214851
Xu L, Li Y, Wu X. IgA vasculitis update: Epidemiology, pathogenesis, and biomarkers. Front Immunol. 2022;13:921864. https://doi.org/10.3389/fimmu.2022.921864 DOI: https://doi.org/10.3389/fimmu.2022.921864
Pillebout E, Sunderkötter C. IgA vasculitis. Semin Immunopathol. 2021;43(5):729-38. https://doi.org/10.1007/s00281-021-00874-9 DOI: https://doi.org/10.1007/s00281-021-00874-9
Hu Y, Yang Y, Chiang B. Immunoglobulin A vasculitis: The clinical features and pathophysiology. Kaohsiung J Med Sci. 2024;40(7):612-20. https://doi.org/10.1002/kjm2.12852 DOI: https://doi.org/10.1002/kjm2.12852
Hočevar A, Tomšič M, Jurčić V, Perdan Pirkmajer K, Rotar Ž. Predicting gastrointestinal and renal involvement in adult IgA vasculitis. Arthritis Res Ther. 2019;21(1):302. https://doi.org/10.1186/s13075-019-2089-2 DOI: https://doi.org/10.1186/s13075-019-2089-2
Ozen S, Pistorio A, Iusan SM, Bakkaloglu A, Herlin T, Brik R, et al. EULAR/PRINTO/PRES criteria for Henoch-Schönlein purpura, childhood polyarteritis nodosa, childhood Wegener granulomatosis and childhood Takayasu arteritis: Ankara 2008. Part II: Final classification criteria. Ann Rheum Dis. 2010;69(5):798-806. https://doi.org/10.1136/ard.2009.116657 DOI: https://doi.org/10.1136/ard.2009.116657
Hočevar A, Rotar Z, Jurčić V, Pižem J, Čučnik S, Vizjak A, et al. IgA vasculitis in adults: the performance of the EULAR/PRINTO/PRES classification criteria in adults. Arthritis Res Ther. 2016;18:58. https://doi.org/10.1186/s13075-016-0959-4 DOI: https://doi.org/10.1186/s13075-016-0959-4
Roache-Robinson P, Killeen RB, Hotwagner DT. IgA Vasculitis (Henoch-Schönlein Purpura). En: StatPearls [Internet]. StatPearls Publishing; 2023 [citado 11 de marzo de 2025]. Disponible en: https://www.ncbi.nlm.nih.gov/sites/books/NBK537252/
Sestan M, Jelusic M. Diagnostic and Management Strategies of IgA Vasculitis Nephritis/Henoch-Schönlein Purpura Nephritis in Pediatric Patients: Current Perspectives. Pediatr Health Med Ther. 2023;14:89-98. https://doi.org/10.2147/PHMT.S379862 DOI: https://doi.org/10.2147/PHMT.S379862
Hetland LE, Susrud KS, Lindahl KH, Bygum A. Henoch-Schönlein Purpura: A Literature Review. Acta Derm Venereol. 2017;97(10):1160-6. https://doi.org/10.2340/00015555-2733 DOI: https://doi.org/10.2340/00015555-2733
Trnka P. Henoch-Schönlein purpura in children. J Paediatr Child Health. 2013;49(12):995-1003. https://doi.org/10.1111/jpc.12403 DOI: https://doi.org/10.1111/jpc.12403
Garcia N, Jiminez V, Heudebert A. IgA Vasculitis. J Gen Intern Med. 2022;37(15):4008-9. https://doi.org/10.1007/s11606-022-07745-5 DOI: https://doi.org/10.1007/s11606-022-07745-5
Castañeda S, Quiroga-Colina P, Floranes P, Uriarte-Ecenarro M, Valero-Martínez C, Vicente-Rabaneda EF, et al. IgA Vasculitis (Henoch-Schönlein Purpura): An Update on Treatment. J Clin Med. 2024;13(21):6621. https://doi.org/10.3390/jcm13216621 DOI: https://doi.org/10.3390/jcm13216621
Bluman J, Goldman RD. Henoch-Schönlein purpura in children: limited benefit of corticosteroids. Can Fam Physician Med Fam Can. 2014;60(11):1007-10.
Downloads
Published
Issue
Section
License
Copyright (c) 2025 Copyright: © Los autores. Publicado por Gaceta Médica JBG.
This work is licensed under a Creative Commons Attribution 4.0 International License.
