Neonatal Portal Vein Thrombosis: A Case Report

Authors

DOI:

https://doi.org/10.61708/y4smnm23

Keywords:

neonate, thrombosis, portal vein, umbilical catheter

Abstract

Thrombotic events in neonates are rare pathologies associated with the use of umbilical catheters. Venous thromboses, especially portal vein thrombosis (DVT), are more common than arterial ones. They can extend to the intrahepatic portal branches and cause serious complications, such as portal hypertension. Early detection and timely treatment are essential to avoid serious complications. We present the case of a preterm neonate transferred at two days of age, who had an umbilical catheter placed for venous support in the hospital of origin. During hospitalization, an imaging study was performed for signs of cholestasis, finding an image suggestive of thrombosis in the left branch of the portal vein. The diagnosis was confirmed by Doppler ultrasound and triphasic tomography. Treatment was initiated with low molecular weight heparin as an anticoagulant. After the start of treatment, a decrease in bilirubin levels and progressive improvement of clinical signs will be observed. There were no serious complications such as portal cavernomatosis or portal hypertension and the patient had a favorable evolution without requiring surgical intervention.

Thrombosis associated with umbilical catheter in neonates is a rare complication, but with high morbidity. Early diagnosis through imaging studies and initiation of early anticoagulant therapy are crucial to improve prognosis and avoid serious complications.

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Author Biographies

  • Ambar Armijos, Hospital Dr. Roberto Gilbert Elizalde. Guayaquil, Ecuador

    Médico Residente de Posgrado de Pediatría. Hospital Dr. Roberto Gilbert Elizalde. Guayaquil, Ecuador.

  • Brigitte Secaira, Hospital Dr. Roberto Gilbert Elizalde. Guayaquil, Ecuador

    Médico Residente de Posgrado de Pediatría. Hospital Dr. Roberto Gilbert Elizalde. Guayaquil, Ecuador.

  • Daniel Kwiek, Hospital Dr. Roberto Gilbert Elizalde. Guayaquil, Ecuador

    Médico Residente de Posgrado de Pediatría. Hospital Dr. Roberto Gilbert Elizalde. Guayaquil, Ecuador.

  • Reyma Mosquera, Hospital Dr. Roberto Gilbert Elizalde. Guayaquil, Ecuador

    Médico Especialista de Pediatría. Sub-especialista Neonatología. Hospital Dr. Roberto Gilbert Elizalde. Guayaquil, Ecuador.

  • Elena Crespo, Hospital Dr. Roberto Gilbert Elizalde. Guayaquil, Ecuador

    Médico Especialista de Pediatría. Sub-especialista Neonatología. Hospital Dr. Roberto Gilbert Elizalde. Guayaquil, Ecuador.

  • David Rosas, Hospital Dr. Roberto Gilbert Elizalde. Guayaquil, Ecuador

    Médico Especialista de Pediatría. Sub-especialista Neonatología. Hospital Dr. Roberto Gilbert Elizalde. Guayaquil, Ecuador.

  • Alex Villalta, Hospital Dr. Roberto Gilbert Elizalde. Guayaquil, Ecuador

    Médico Especialista en Imagenología. Hospital Dr. Roberto Gilbert Elizalde. Guayaquil, Ecuador.

References

Jiménez CE, Randial L, Silva I, Hossman-Galindo M, Bravo M, Moreno O. Ex-trahepatic portal vein thrombosis, surgical management with meso-rex shunt. Series of 3 cases. Revista Colombiana de Cirugia. 2021;36(1):98-109. https://doi.org/10.30944/20117582.574 DOI: https://doi.org/10.30944/20117582.574

Ruiz-Mejía C, Jaramillo-Jaramillo LI, María Martínez-Sánchez L, Villegas-Alzate JD, Felipe Álvarez-Hernández L, Builes- Restrepo LN. Trombosis asociada a catéter venoso central neonatal: revisión narrativa de la bibliografía Neonatal central venous catheter-associated thrombosis: a narrative review of the literature [Internet]. Vol. 42, Acta Pediatr Mex. 2021. Available from: www.actapediatrica.org.mx

Bacciedoni V, Attie M, Donato H. Thrombosis in newborn infants. Arch Argent Pediatr. 2016 Apr 1;114(2):159-66.

Greenway A, Massicotte MP, Monagle P. Neonatal thrombosis and its treatment. Vol. 18, Blood Reviews. Churchill Livingstone; 2004. p. 75-84. https://doi.org/10.1016/S0268-960X(03)00042-0 DOI: https://doi.org/10.1016/S0268-960X(03)00042-0

Peña Basulto A, Santiesteban Rodríguez B, Reynaldo Corpas R. Prehepatic portal hypertension due to umbilical catheterization: a case report. Revista Estudiantil HolCien [Internet]. 2023 Feb 23;4(1). Available from: https://revholcien.sld.cu/index.php/holcien/article/view/242/129

Revilla PM, Ruiz Del Olmo I, Pablo J, Íñiguez G. Trombosis venosa y arterial extracerebral: diagnóstico, prevención y tratamiento. 2021;811-34. Available from: www.aeped.es/protocolos/

CHAN AK, DEVEBER G, MONAGLE P, BROOKERS LA, MASSICOTTES P.M. Venous thrombosis in children. Journal of Thrombosis and Haemostasis. 2003;1:1443-55. https://doi.org/10.1046/j.1538-7836.2003.00308.x DOI: https://doi.org/10.1046/j.1538-7836.2003.00308.x

Altuna D. Trombosis en Pediatría [Internet]. 2013 [cited 2024 Jul 26]. Available from: https://www.sah.org.ar/revistasah/numeros/vol17.n.extra.38.43.pdf

Singal AK, Kamath PS, Tefferi A. Mesenteric venous thrombosis. In: Mayo Clinic Proceedings. Elsevier Ltd; 2013. p. 285-94. https://doi.org/10.1016/j.mayocp.2013.01.012 DOI: https://doi.org/10.1016/j.mayocp.2013.01.012

Monagle P, Chan AKC, Goldenberg NA, Ichord RN, Journeycake JM, Nowak-Göttl U, et al. Antithrombotic therapy in neonates and children: Antithrombotic therapy and prevention of thrombosis, 9th ed: American college of chest physi-cians evidence-based clinical practice guidelines. Chest. 2012;141(2 SUPPL.):e737S-e801S. https://doi.org/10.1378/chest.11-2308 DOI: https://doi.org/10.1378/chest.11-2308

Correa Barria DA, Díaz Olivares MA, Lara López SE, Valenzuela Aguilera MA. Trombosis en el recién nacido. Revista Pediatrica ElectronicaLILACS [Internet]. 2021 Apr 1 [cited 2024 Aug 29];18:45-9. Available from: https://www.revistapediatria.cl/volumenes/2021/vol18num1/pdf/TROMBOSIS_RECIEN_NACIDO.pdf

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Published

2024-12-30

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Section

Case report

How to Cite

1.
Armijos A, Secaira B, Kwiek D, Mosquera R, Crespo E, Rosas D, et al. Neonatal Portal Vein Thrombosis: A Case Report. Gac Med JBG [Internet]. 2024 Dec. 30 [cited 2026 Mar. 7];2(3):58-62. Available from: https://gacetamedicajbgmedec.biteca.online/index.php/GMJBG/article/view/32
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